Needles no more: Proteins slip vaccines under skin

Photo: Skedonk

Prediction: By 2015, vaccines will become available “off the shelf” (image, “now available without a prescription”), thanks to needle-free delivery. — MB

Some Americans will receive dozens of vaccines in their lifetimes.

That’s a lot of shots, and boosters, for doctors and patients to keep track of.

Adding to the confusion, University of Michigan scientists say we will soon be able to inoculate ourselves, at home, by applying vaccines to their skin.

The researchers have devised a “non-invasive” way to use a specific protein to help vaccines pass through the skin’s outermost layers.

Making vaccines easier to administer, the Michigan scientists say, should boost patient compliance.

From a report, today:

“One particularly interesting aspect of this new non-invasive method is that the ‘boosters’ required for many vaccination protocols could be administered by the patients themselves. This could increase the success of vaccination campaigns in poor and remote regions of the world, where medical facilities are scarce.”

via Angewandte Chemie International Edition – Wiley InterScience.

EM field, behind right ear, suspends morality

Morally impaired? Photo: Eddie Van 3000/Flickr CC

This new finding, from MIT, should cause scientists to more closely examine the risks to human health posed by mobile phones and other wireless, personal technologies. — M.B.

MIT neuroscientists believe they have isolated the brain region — just behind the right ear — where moral judgements take place.

And they can suspend someone’s ability to judge right from wrong, simply by generating a magnetic field near the same spot where many of us hold our cellular phones and wireless, Bluetooth, headsets.

The researchers’ findings, announced today:

“In both experiments, the researchers found that when the right TPJ (right temporo-parietal junction) was disrupted, subjects were more likely to judge failed attempts to harm as morally permissible.”

The technique used by the MIT scientists, transcranial magnetic stimulation (TMS), has been described as one that creates “virtual lesions” on the brain.

Neurostar makes a device that affects mood and behavior, from outside the head. Photo: Neuronetics

And although TMS’s long term effects on health are not well understood (similar amounts of electromagnetic radiation have been linked to increased cancer risk), the treatment is becoming increasingly popular for everything from tinnitus to depression.

The US military also hopes to use TMS to keep soldiers fighting, without the need to stop for sleep.

via Moral judgments can be altered.

See what else Hub scientists getting up to, by following my Boston Globe column, here.

Scientists: Vaccines provide "herd immunity"

Naked apes. Photo: Peter O'Connor/Flickr CC

By using “herd,” the scientific community belies its insensitivity, if not its outright contempt, for the rest of humanity.

Dose the kids, protect the “herd.” That’s the language hardhearted epidemiologists are using to describe how vaccinations work to protect human populations:

“An unusual study done in 49 remote Hutterite farming colonies in western Canada has provided the surest proof yet that giving flu shots to schoolchildren protects a whole community from the disease. Although previous studies have demonstrated what scientists call ‘herd immunity,’ none have been so incontrovertible, because they were done in less isolated places with more sources of flu passing through.

Stanhope to English, Irish, herd: "Go to hell."

Credit Canadian conspiracy historian Alan Watt, for noting how scientists use the word, “herd,” in a way that fails to jibe with any citation in popular dictionaries.

The scientists are, however, using the same, precise language of that obnoxious prig, the 4th Earl of Chesterfield,  Philip Dormer Stanhope (click the excerpt below, for the full text):

via NYT: Flu shots in kids provide ‘herd immunity’ – The New York Times- msnbc.com.

Pot as "miracle drug": It's complicated

Andrew Sullivan. (Photo: Trey Ratcliff/Flickr CC)

Marijuana not only doesn’t kill brain cells, as do alcohol and heroin — and depression –   it grows ‘em back, Andrew Sullivan asserts.

He quotes some recent rat brain research:

The team found that rats treated with HU-210 on a regular basis showed neurogenesis – the growth of new brain cells in the hippocampus. This region of the brain is associated with learning and memory, as well as anxiety and depression.

The effect is the opposite of most legal and illicit drugs such as alcohol, nicotine, heroin, and cocaine. “Most ‘drugs of abuse’ suppress neurogenesis,” Zhang says. “Only marijuana promotes neurogenesis.”

For me, the key phrase in this excerpt (above), is “drugs of abuse.” No doubt, pot is one of them — experience tells us this. (There is also massive anecdotal evidence of pot’s benefits.)  And the drug’s effects on the brain are more complex than Sullivan’s post suggests.

Still, as Lester Grinspoon says, that pot will eventually emerge as the gold standard among anti-anxiety medicines.

I also agree with Sullivan: Reason dictates that pot must be made legal, and fully available to scientists, if we are serious about relieving human suffering.

via The Miracle Of Marijuana – The Daily Dish | By Andrew Sullivan.

High-hatted medical writers forget government, Big Pharma evils

Science writers, several of whom are flogging their entries into the genre I hereby dub, science backlash, complain that mainstream research is becoming a tough sell, as consumers re-discover the efficacy of folk medicine and a healthy diet.

But one Knight Science Fellow at MIT (I thought these lucky bastards were barred from publishing while doing their $60K fellowships) identifies the real reason that people don’t trust mainstream medicine:

the real source of this irrational behavior lies not in public ignorance but rather in an understandable reaction against the problems with our health care system and the documented abuses and profiteering of some pharmaceutical companies.

via: Slate

Here’s a a link to one Globe op-ed that got me thinking about this issue:

I was astounded…to read recently, in a popular newsletter for pediatricians, a column by a pediatrician stating that he would not recommend the vaccine to his patients. His arguments were that the illness was relatively mild and the vaccine might not be safe.

via: Boston Globe

Also, check out: Book review: A coffee enema for a health writer « Boston Health News.

$125 for state behavior surveillance system

Photo: Caitlin B/Flickr CC

Photo: Caitlin B/Flickr CC

The government wants to know what makes masses eat and smoke so much.

The Centers for Disease Control and Prevention, with Recovery Act dollars, is looking for plans that will “change the environment in which eating, tobacco use, and physical activity occur, and impact population groups rather than individuals.”

Any proposal must be crafted toward changing group behavior, rather than helping individuals, according to the grant announcement:

State Supplemental Funding for Healthy Communities, Tobacco Control. Diabetes Prevention and Control. and Behavioral Risk Factor Surveillance System

via Grants.gov – Find Grant Opportunities – Opportunity Synopsis.

Our betters are shooting blanks

Photo: Erik Mill. Flickr/CC

The question is, who is defining “high quality,” here:

“The results support the suggestion that genes that are good for males may often be bad for their mates. Therefore, in beetles at least, multiple mating does not award females with genetic benefits,” says Göran Arnqvist.

via Males Of High Genetic Quality Are Not Very Successful At Fertilizing Eggs.

It ain't skin. It's "skin-like"

Tufts bioengineers grow mucosal cells:

BOSTON (July 21, 2009) — Dental and tissue engineering researchers at Tufts University School of Dental Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts have harnessed the pluripotency of human embryonic stem cells (hESC) to generate complex, multilayer tissues that mimic human skin and the oral mucosa (the moist tissue that lines the inside of the mouth). The proof-of-concept study is published online in advance of print in Tissue Engineering Part A.

via Skin-like tissue developed from human embryonic stem cells | h+ Magazine.

Cops scour the land for angels of death

Photo: CC/tanya petrova

Photo: CC/tanya petrova

The “death with dignity” crowd in the US is in a state over law enforcement’s efforts to quash would-be Jack Kervorkians:

The internet is being kept under close watch by law enforcement to find more victims to back up their dubious prosecutions in Georgia and Arizona. Thus this is a time to be extra cautious and discreet. At trial, the defendants will be rigorously defended.

This harassment is most likely a right-wing backlash to our movement’s law reform successes in Oregon, Washington and Montana. We shall proceed.

via Law enforcement searching America for ‘assisted suicide’ cases | Assisted-Suicide Blog.

Scientists advance safety of nanotechnology

Photo: CC/US Army

Photo: CC/US Army

Nanoparticles being used in medicine are deadly if inhaled. But they’ve got a drug for that, already:

In a study published online today Thursday 11 June in the newly launched Journal of Molecular Cell Biology [1] Chinese researchers discovered that a class of nanoparticles being widely developed in medicine – ployamidoamine dendrimers PAMAMs – cause lung damage by triggering a type of programmed cell death known as autophagic cell death. They also showed that using an autophagy inhibitor prevented the cell death and counteracted nanoparticle-induced lung damage in mice.

via Scientists advance safety of nanotechnology.